[pt 5 of reqs] i’m back babeyyy

2021.12.08 06:43 Better_Case251 [pt 5 of reqs] i’m back babeyyy

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2021.12.08 06:43 mykl66 Fox News Christmas Tree Fire: NYPD Arrests Possible Arson Suspect

submitted by mykl66 to newyork [link] [comments]


2021.12.08 06:43 The_King_of_Cookies Should MnK be on Consoles

Do you guys think that the game would be more balanced on console if they added MnK as a feature on Xbox and PlayStation? (I’m not mentioning Nintendo switch cause uhhhhh people play on switch?)
submitted by The_King_of_Cookies to apexlegends [link] [comments]


2021.12.08 06:43 Fantastic_Ad_928 I can buy an e-wizard even if i have him maxed?

I can buy an e-wizard even if i have him maxed? submitted by Fantastic_Ad_928 to ClashMini [link] [comments]


2021.12.08 06:43 custom_wp Telegram channel / group NFT HUNTER . 👥 1662 | 🧩 #Cryptocurrency | 🗣 #English . 🔗 https://ift.tt/3EHLtBq

Telegram channel / group NFT HUNTER . 👥 1662 | 🧩 #Cryptocurrency | 🗣 #English . 🔗 https://ift.tt/3EHLtBq submitted by custom_wp to Telegram_Directory [link] [comments]


2021.12.08 06:43 wreckingballhaha Have a chat with Flurry Finance team, Mike Ting and Lawrence Wong at 11:00am UTC today on telegram 👀See you there😉

Have a chat with Flurry Finance team, Mike Ting and Lawrence Wong at 11:00am UTC today on telegram 👀See you there😉 submitted by wreckingballhaha to FlurryFinance [link] [comments]


2021.12.08 06:43 surveycircle_bot Zuckerreduzierte Süßwaren

Zuckerreduzierte Süßwaren submitted by surveycircle_bot to SurveyCircle_de [link] [comments]


2021.12.08 06:43 VulgarPotHead Tongue twister, seize the line

Tongue twister, seize the line submitted by VulgarPotHead to TempleOfVulgarPotHead [link] [comments]


2021.12.08 06:43 Historical_Job_8609 Orthocell finds further success in clinical tendon study

Orthocell finds further success in clinical tendon study submitted by Historical_Job_8609 to stemcells [link] [comments]


2021.12.08 06:43 amrmaro Face Recognition System (Mask Detection, Emotion, Gender and Age Estimation)

Face Recognition System (Mask Detection, Emotion, Gender and Age Estimation) submitted by amrmaro to artificial [link] [comments]


2021.12.08 06:43 USAFProspect2021 Looking for Army commission statistics

First and foremost I list the following information with no means to show off or boast but to illustrate the whole scope of my situation.
I graduated college May of 2020 with a Bachelors in Criminal Justice with a 3.754 GPA with Summa Cum Laude honors. I just took my ASVAB this week and got a 96 AFQT score with a 130 GT score. I did my own research and I know I am eligible (in terms of GPA & ASVAB score) to apply for OCS.
However, I do have a criminal past (one minor misconduct offense). Looking at army regs, my offense would need a battalion commander approval through the enlisted route. I am actively working with a recruiter and he is heavily influencing me to enlist and from there just go green to gold because of the difficulties that will come with processing my packet for OCS (which I do not mind doing so as long as a recruiter does their do diligence & I am ultimately denied)
He said along the lines of "I've had prior applicants try to go the OCS route and their packets were not selected and they all had clean records". From what I have read online civilian applicants and active/enlisted applicants do not compete for the same spots. My question is how valid is his statement because to me it seems like he just do not want to process my packet for OCS because of the extra paperwork.
submitted by USAFProspect2021 to Militaryfaq [link] [comments]


2021.12.08 06:43 jacktacular A SARS-CoV-2 lore dump.

opening meme: i am neither an immunologist nor a doctor, but i do have a background in science & have been following this pandemic since the genome was released in january 2020.
STRUCTURE & REPLICATION:
a summary of the general structure of SARS-CoV-2 is as follows: a helical positive-sense single-stranded RNA wrapped in a Nucleocapsid (N) protein forms the center. surrounding this is a lipid bilayer with 3 types of structural proteins: the Membrane (M), the Envelope (E), and the Spike (S). E and M proteins are boring; they assist in membrane fusion and replication respectively and don't do that much else.
the N protein is interesting because it is the body's main target for antibodies after the S protein, although it is contained inside the virus particle. even more, OG SARS famously requires all of E, M, and N in order to fully form a virus particle, indicating that this may have a greater role in the infectious cycle of SARS-CoV-2.
the S protein has 2 subunits: S1, which contains the Receptor-Binding Domain (RBD) that attaches to the infamous Angiotensin Converting Enzyme 2 (ACE2), and S2 subunit which facilitates the fusion of the M protein to the host cell membrane. this is where mutations meaningful, as changes will affect both its ability to evade immune response and its fitness bonding to the viral entry site.
after the RBD binds to the domain of the receptor, the S protein is cleaved by a transmembrane serine protease, succinctly named TMPRSS2 and neuropilin-1. this exposes a fusion peptide which allows the lipids and proteins to fuse with the membrane of the host's cell, releasing the RNA into the cytoplasm. from here, the central dogma of molecular biology takes over, and the genetic code is converted into proteins.
while this pathogen's final form contains 29 proteins, initially only two polyproteins are built. these are cut up and modified to form:
-the 4 previously discussed structural proteins, -16 non-structural proteins (nsp) that form a replication & transcription complex to perpetuate the process, and -9 accessory proteins.
these accessory proteins seem to fuck with your immune system, blow your cells up, and other bad things, as well as being a large determining factor in the lethality and transmissibility of the virus, although the exact mechanisms are not yet elucidated because many of these proteins are not homologous to any other currently-known structures.
the most fascinating component contained in the code is nsp14, a protein associated with the proof-reading of the replicating strands of RNA. normally, these types of viruses are prone to mutation, as they don't have the redundant storage that we do with DNA. for sake of comparison, the influenza type a virus mutates at a rate of ~2x10-6-2x10-4 base pairs per replication cycle, whereas these betacoronaviruses are several orders of magnitude below this, averaging ~9x10-7 nucleotide changes per genome replication which is ~100x less. the substitutions seems to be directed as well, whether by natural selection or physical process, as shown in parts of the S protein here
NATURAL IMMUNITY:
the immune response from natural infection seems to differ depending on the severity of disease, however this is contested. asymptomatic and severe cases don't seem to generate as long-lasting or robust neutralization compared to the protection conferred by vaccination.
the main difference between immunity conferred from a primary infection and vaccination is a broader range of antibodies produced in the body. the exact role of these antibodies is currently not well understood. some data correlates increased N protein antibody titers with worse clinical outcomes, while other studies suggest it helps curb detrimental cytokine responses. i will spare you the long list of preprints, but trust me when i say it is unlikely that we have a proper answer while this pandemic is still relevant.
overall, there is no consensus on whether or not there is any immunological benefit to natural infection over vaccination, especially once you consider the risk of long-term effects.
VACCINES:
the currently available vaccines (which are all technically mRNA vaccines by the way) only produce an immune response against the S protein. while there is less variety in protein targets, it does seem that the range of RBDs it trains your body to attack is more diverse than recovered subjects. however, some the strongest observed levels of S protein neutralizing antibodies is in those with a previous infection who got vaccinated.
the presences of antibodies can be detected for up to six months following vaccination. being immune, that immunity waning, and being exposed to variants with only partial protection is an incredibly complex equilibrium that is well illustrated in this model if you have a any sort of calculus background. the partial derivatives are pretty elegant.
the development and production of the vaccines are things that have been previously covered on stream, and the full story of the 40-year journey to where we are today is truly a monument to human progress. further, with the resulting lowered development costs we can now theoretically create vaccines that cover all known major virus phylogenies, and reduce or eliminate the next plandemic.
ANTIBODY-DEPENDENT ENHANCEMENT:
ADE is a phenomenon where non- or sub-neutralizing antibodies bind to a pathogen and somehow worsen the clinical outcomes of various diseases. one of the best studied instances of this happening is with Dengue fever: there are 4 serotypes of the mosquito-transmitted virus, and the antibodies from one strain attacking another facilitate the transport into immune cells known as monocytes where its replication is more efficient than in other cells.
the other major mechanism that can result in problems is the formation of an immune complex, where a group of antibodies and foreign cells form a clump in the airway tissues. this triggers the secretion of cytokines which cause inflammation. both of these are pictured succinctly in this diagram.
we know that the virus must enter via the ACE2 receptor, and this occurs via the RBD of the spike protein; as such there is no other currently accepted target for neutralizing the pathogen and minimizing progression of the illness. while the SARS-CoV-2 virus shows no signs of enhanced replication in immune cells like Dengue fever does, the conflicting data on the N protein antibodies with regards to inflammation seems to be a cause for concern.
the real meme inside the meme is that this is accidentally based on a true story: initial trials with SARS vaccines ranged from fine, to not great.
BONUS MEME:
ACE2 is a crucial part of the renin-angiotensin system which regulates your blood pressure, and these receptors can be found not only in the lung epithelial tissue, but the heart, testis, small intestine, and, most interestingly, the insulin-producing beta cells of the pancreas. this has been linked to several instances of hyperglycemia and other signs of diabetes. it makes me smile to think that a bunch of white rural Americans are slowly closing a racial health disparity by dragging the average down. the party of Lincoln forsure.
closing meme: inb4 "i bet you wrote this because your mom grounded your axioms so hard that you revenge fucked your gay twin brother in college since it’s morally neutral."
bonus bonus meme: since Destiny is non-binary, isn't calling him a cuck technically transphobic now?
submitted by jacktacular to Destiny [link] [comments]


2021.12.08 06:43 mrsgreensworth Actual footage of Rory Burns’ footwork

Actual footage of Rory Burns’ footwork submitted by mrsgreensworth to Cricket [link] [comments]


2021.12.08 06:43 lss_mobile_mod_02 Image

Image submitted by lss_mobile_mod_02 to RedditMobTest [link] [comments]


2021.12.08 06:43 Formal_Cellist_6288 IAF Helicopter crashes with CDS. bipin rawat and other high ranking military officials onboard.

IAF Helicopter crashes with CDS. bipin rawat and other high ranking military officials onboard. submitted by Formal_Cellist_6288 to IndiaSpeaks [link] [comments]


2021.12.08 06:42 bread-in-captivity Which new Christmas traditions did you start as you grew up or would you like to start when you grow up?

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2021.12.08 06:42 MrBurns32X The British-American Tobacco company information disc Germany (Philips CD-i)

The British-American Tobacco company information disc Germany (Philips CD-i) submitted by MrBurns32X to CDInteractive [link] [comments]


2021.12.08 06:42 Silvrin Is it worth it?

Quick question. Is it worth it to buy RF4 special on steam now, or to wait until the Christmas Sale?
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2021.12.08 06:42 butttron4 Went for an interview, pleasently surprised

So I like to "window shop" for jobs in my area, it's not me actively looking for a job but my resume just ends up in people's indeed stuff. It's a good way to keep updated on the earnings in your industry other options out there and most importantly wages.
Got a call from a man the other with a start up business that has recently bitten off more than they can chew so they're looking for someone to help fast. I came in, did a test (showcases your skills, pretty standard practice) and we talked about expectations.
The hours are long but they pay overtime and have receipts to show for it, pay about $10 more than industry standard and are looking at benefit packages for the place. The owner said he was always scraping by on salary at his old work so when he opened this new business he wanted to make sure his employees are well taken care of.
We need more bosses like this, paying fair due to experiencing what it's like from the other side.
submitted by butttron4 to antiwork [link] [comments]


2021.12.08 06:42 larryfacetogetlucky Why is it that Cannabis greatly increases the pattern matching capabilities

And along with, the likelihood of spurious matches. Like what are the regions impacted by this claim. Can these pattern matching identifiers get a boost from a vitamin or prescription drug elsewhere?
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2021.12.08 06:42 Goodn8_Robicheaux My bumble date. Dm to make me horny for her so I can fuck her good tonight.

My bumble date. Dm to make me horny for her so I can fuck her good tonight. submitted by Goodn8_Robicheaux to sexy_reallife_ladiess [link] [comments]


2021.12.08 06:42 jordanbelly Top 5 Best Pump Paintball Guns In 2021: Which Is The Best For You?

If you are going from beginner to passionate and professional paintball, you should upgrade your paintball gun. And with durability, accuracy, and convenience, Azodin KAOS 3 is a name worth considering first.
See more: https://paintballadvisors.com/best-pump-paintball-guns/
#paintballadvisors #paintball
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2021.12.08 06:42 No_Membership_9946 3k euro POE MTX Account.

Greetings. This is an account i have been buying MTX for over the last 2 - 3 years. However, its time for it to go. So im selling it for 1000 Euros.
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2021.12.08 06:42 AutoNewspaperAdmin [World] - Myanmar: Soldiers accused of shooting, burning 13 villagers | BBC

[World] - Myanmar: Soldiers accused of shooting, burning 13 villagers | BBC submitted by AutoNewspaperAdmin to AutoNewspaper [link] [comments]


2021.12.08 06:42 Abhi2668 Canadian Study Permit sufficient for Mexico Visit

I want to visit Mexico, but my passport requires me to apply for a visa. Would it be sufficient having a Canadian study permit as I read somewhere that this would suffice to travel to Mexico temporarily. This is quite urgent. ( I have an Indonesian Passport and am studying in Canada.)
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